Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny

Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny

Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny ukierunkowany na gospodarza w patologicznie odmiennych mysich modelach gruźlicy 

Efforts to develop simpler and shorter-course therapies for tuberculosis have included a concentrate on host-directed remedy (HDT). The aim of HDT is to modulate the host response to an infection, thereby bettering immune defenses to scale back the length of antibacterial remedy and/or the quantity of lung harm.

As a mediator of innate and adaptive immune responses concerned in eliminating intracellular pathogens, autophagy is a possible goal for HDT in tuberculosis. As a result of Mycobacterium tuberculosis modulates mammalian goal of rapamycin (mTOR) signaling to impede autophagy, pharmacologic mTOR inhibition may present efficient HDT. mTOR exists inside two distinct multiprotein complexes, mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2).

Rapamycin and its analogs solely partially inhibit mTORC1. We hypothesized that novel mTOR kinase inhibitors blocking each complexes would have expanded therapeutic potential. We in contrast the consequences of two mTOR inhibitors: rapamycin and the orally obtainable mTOR kinase area inhibitor CC214-2, which blocks each mTORC1 and mTORC2, as adjunctive therapies in opposition to murine TB, when added to the first-line routine (RHZE) or the novel bedaquiline-pretomanid-linezolid (BPaL) routine.

Neither mTOR inhibitor affected lung CFU counts after 4-Eight weeks of remedy when mixed with BPaL or RHZE. Nonetheless, addition of CC214-2 to BPaL and RHZE was related to considerably fewer relapses in C3HeB/FeJ in comparison with addition of rapamycin and, in RHZE-treated mice, resulted in fewer relapses in comparison with RHZE alone. Due to this fact, CC214-2 and associated mTOR kinase inhibitors could also be simpler candidates for HDT than rapamycin analogs and will have the potential to shorten the length of TB remedy.

 

patogeny2019
patogeny2019

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-1mg 1 mg
EUR 2030.4

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-100g 100 µg Ask for price

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-10g 10 µg
EUR 2150

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-50g 50 µg Ask for price

Mycobacterium tuberculosis antigen EsaT-6 (Rv3875) Antibody

abx140048-01mg 0.1 mg
EUR 510

Mycobacterium tuberculosis antigen EsaT-6 (Rv3875) Antibody

abx140048-100g 100 µg
EUR 350

Recombinant Mycobacterium tuberculosis ESAT-6

DAGH171 1 mg
EUR 630
Description: Recombinant

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-1ml 1 ml
EUR 727.2

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-200l 200 µl
EUR 537.5

Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

1-CSB-YP363658MVZ
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Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB(esxB) expressed in Yeast

Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

1-CSB-EP363658MVZ
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Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB(esxB) expressed in E.coli

Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH)

1-CSB-EP363659MVZ
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Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH(esxH),partial expressed in E.coli

Mycobacterium tuberculosis (ESAT) mouse monoclonal antibody, clone RSB14

3ES6-RSB14 1 mg Ask for price

Mycobacterium tuberculosis (ESAT) mouse monoclonal antibody, clone RSB34

3ES6-RSB34 1 mg Ask for price

Mycobacterium tuberculosis Antibody

abx022066-1mg 1 mg
EUR 1220.4

Mycobacterium tuberculosis Antibody

abx022067-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis Antibody

abx022073-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis Antibody

abx022087-1mg 1 mg
EUR 994.8

Mycobacterium tuberculosis Antibody

abx022088-1mg 1 mg
EUR 994.8

Mycobacterium tuberculosis Antibody

abx022089-1mg 1 mg
EUR 944.4

Mycobacterium tuberculosis Antibody

abx022090-1mg 1 mg
EUR 944.4

Mycobacterium tuberculosis Antibody

abx023092-1ml 1 ml
EUR 718.8

Mycobacterium tuberculosis antibody

20-MR50 1 mg
EUR 110
Description: Rabbit polyclonal Mycobacterium tuberculosis antibody

Mycobacterium tuberculosis Antibody

GWB-37A518 0.5 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-52959A 1 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-613CF2 1 ml Ask for price

Mycobacterium tuberculosis, Antibody

GWB-1A49B9 0.1 mg Purified Ask for price

Mycobacterium tuberculosis Antibody

GWB-AE5BA3 1 ml Ask for price

Mycobacterium Tuberculosis Antibody

GWB-EF714E 1 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-CAE926 1 ml Ask for price

Mycobacterium tuberculosis Antibody

abx022066-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022066-80l 80 µl
EUR 1200

Mycobacterium tuberculosis Antibody

abx022067-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022067-80l 80 µl
EUR 1287.5

Mycobacterium tuberculosis Antibody

abx022073-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022073-80l 80 µl
EUR 1287.5

Mycobacterium tuberculosis Antibody

abx023092-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx023092-80l 80 µl
EUR 1012.5

Recombinant purified (E. coli) Mycobacterium tuberculosis antigen (6kDa/ESAT-6)

MTB06-R 100 ug
EUR 927.6

Recombinant Mycobacterium Tuberculosis ESAT-6 Protein (aa 1-99) [His]

VAng-Lsx06137-100g 100 µg
EUR 717.6
Description: Mycobacterium Tuberculosis (H37Rv) ESAT-6, recombinant protein from E. coli.

Recombinant Mycobacterium Tuberculosis ESAT-6 Protein (aa 1-99) [His]

VAng-Lsx06137-1mg 1 mg
EUR 3686.4
Description: Mycobacterium Tuberculosis (H37Rv) ESAT-6, recombinant protein from E. coli.

Mycobacterium tuberculosis Antibody (HRP)

abx023091-1ml 1 ml
EUR 777.6

Mycobacterium tuberculosis Antibody (HRP)

abx023091-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody (HRP)

abx023091-80l 80 µl
EUR 1150

Mycobacterium tuberculosis Antibody (FITC)

abx023089-1ml 1 ml
EUR 718.8

Mycobacterium tuberculosis Antibody (FITC)

GWB-96010D 0.5 ml Ask for price

Mycobacterium tuberculosis Antibody (FITC)

abx023089-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody (FITC)

abx023089-80l 80 µl
EUR 1150

Mycobacterium tuberculosis Antibody (38kDa)

GWB-5CFFC2 1 mg Ask for price

Mycobacterium tuberculosis Antibody (CFP10)

GWB-T00317 1 mg Ask for price

Mycobacterium tuberculosis Antibody (CFP10)

GWB-T00318 1 mg Ask for price

Mycobacterium tuberculosis Antibody (CFP10)

GWB-T00380 1 mg Ask for price

Mycobacterium tuberculosis Antibody (16kDa)

GWB-89DFC6 1 mg Ask for price

Mycobacterium tuberculosis Antibody (38kDa)

GWB-904A2B 1 mg Ask for price

Mycobacterium tuberculosis Antibody (16kDa)

GWB-A4468D 1 mg Ask for price

Mycobacterium tuberculosis Antibody (38kDa)

GWB-D365BE 1 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

CSB-YP363658MVZ 6400 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB(esxB)

AP72990 each Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB(esxB)

AP76578 1mg
EUR 2826

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

CSB-EP363658MVZ 3423 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

CSB-EP363658MVZb2 3424 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

RPC25281-100ug 100ug
EUR 817.3

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

RPC25281-20ug 20ug
EUR 479.6

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC22792-100ug 100ug
EUR 721.6

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC22792-1mg 1mg
EUR 2884.7

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC22792-20ug 20ug
EUR 448.1

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC28769-100ug 100ug
EUR 765.5

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC28769-1mg 1mg
EUR 2959.2

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

RPC28769-20ug 20ug
EUR 465.6

Mycobacterium tuberculosis Antibody (Biotin)

abx023090-1ml 1 ml
EUR 718.8

Mycobacterium tuberculosis Antibody (RV3134)

GWB-5F8F15 1 mg Ask for price

Mycobacterium tuberculosis Antibody (RV2623)

GWB-22388D 1 mg Ask for price

Mycobacterium tuberculosis Antibody (Biotin)

abx023090-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody (Biotin)

abx023090-80l 80 µl
EUR 1087.5

Mycobacterium Tuberculosis Antigen Antibody

GWB-824465 0.1 mg Ask for price

Mycobacterium Tuberculosis Antigen Antibody

GWB-7ADDEA 0.2 mg Ask for price

Mycobacterium Tuberculosis Antigen Antibody

GWB-B49A16 0.2 mg Ask for price

Mycobacterium tuberculosis ESAT-6 like protein EsxG Control/blocking peptide

AB-23071-P 100ug
EUR 196.8

Mycobacterium tuberculosis CFP10 Antibody

abx022068-1mg 1 mg
EUR 1111.2

Mycobacterium tuberculosis CFP10 Antibody

abx022069-1mg 1 mg
EUR 1111.2

Mycobacterium tuberculosis CFP10 Antibody

abx022070-1mg 1 mg
EUR 1111.2

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis CFP10 Antibody

abx022069-400l 400 µl Ask for price

Mycobacterium tuberculosis CFP10 Antibody

abx022069-80l 80 µl
EUR 987.5

Mycobacterium tuberculosis CFP10 Antibody

abx022070-400l 400 µl Ask for price

Mycobacterium tuberculosis CFP10 Antibody

abx022070-80l 80 µl
EUR 987.5

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-400l 400 µl Ask for price

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-80l 80 µl
EUR 1287.5

Mycobacterium tuberculosis RV2623 antibody

10R-M139a 1 mg
EUR 736.8
Description: Mouse monoclonal Mycobacterium tuberculosis RV2623 antibody

Mycobacterium tuberculosis RV2623, Antibody

GWB-690473 1 mg Ask for price

Mycobacterium tuberculosis RV2623, Antibody

GWB-E50939 1 mg Ask for price

Mycobacterium Tuberculosis RV1681 Antibody

abx137193-01mg 0.1 mg
EUR 350

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH(esxH),partial

AP71172 1mg
EUR 2826

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH), partial

CSB-EP363659MVZ 3425 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH) ,partial

RPC20136-100ug 100ug
EUR 721.6

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH) ,partial

RPC20136-1mg 1mg
EUR 2884.7

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH) ,partial

RPC20136-20ug 20ug
EUR 448.1

Mycobacterium tuberculosis antigen Tb7.7 Antibody

abx140173-01mg 0.1 mg
EUR 510

Mycobacterium tuberculosis antigen Tb7.7 Antibody

abx140173-100g 100 µg
EUR 350

MYCOBACTERIUM TUBERCULOSIS

GWB-FB7063 0.05 mg Ask for price

Reprezentowanie przenoszenia gruźlicy ze złożonym zakażeniem: podejście do modelowania symulacyjnego opartego na agentach

Goal: A latest research reported a tuberculosis (TB) outbreak through which, amongst newly contaminated people, publicity to extra energetic infections was related to a better likelihood of creating energetic illness. Known as complicated contagion, a number of reexposures to TB inside a brief interval after preliminary an infection is hypothesized to confer a better chance of creating energetic an infection in 1 y. The aim of this text is to develop and validate an agent-based simulation mannequin (ABM) to review the impact of complicated contagion on population-level TB transmission dynamics.

Strategies: We constructed an ABM of a TB epidemic utilizing knowledge from a sequence of outbreaks recorded within the 20th century in Saskatchewan, Canada. We match three dynamical schemes: base, with no complicated contagion; additive, through which every reexposure confers an unbiased threat of activated an infection; and threshold, through which a small variety of reexposures confers a low threat and a excessive variety of reexposures confers a excessive threat of activation.

Outcomes: We discover that the bottom mannequin suits the mortality and incidence output targets greatest, adopted by the edge after which the additive fashions. The edge mannequin suits the incidence higher than the bottom mannequin does however overestimates mortality. All three fashions produce qualitatively lifelike epidemic curves.

Conclusion: We discover that complicated contagion qualitatively modifications the trajectory of a TB epidemic, though knowledge from a high-incidence setting are reproduced higher with the bottom mannequin. Outcomes from this mannequin show the feasibility of utilizing ABM to seize nuances in TB transmission.

Opis przypadku gruźlicy w palcu 

Tuberculosis is a persistent, infectious illness that predominantly impacts the respiratory system. Of the least frequent extrapulmonary types of the illness is cutaneous tuberculosis. We current an uncommon case, which is of cutaneous tuberculosis within the finger, manifesting as an ulcerating, erythematous lesion. This had later unfold to the adjoining tender tissue and bones, inflicting osteomyelitis of the phalanges. It will be significant that physicians keep a excessive index of suspicion when confronted with atypical pores and skin lesions to keep away from the sequelae of the native and disseminated unfold of a tuberculosis an infection.

Gruźlica pozapłucna udająca złośliwość ściany klatki piersiowej: po prostu nigdy nie przestaje zaskakiwać! 

With the emergence of the acquired immunodeficiency syndrome, we witnessed a better incidence of disseminated and extrapulmonary tuberculosis. The an infection websites generally embody lymph nodes, pleura, and osteoarticular areas, though any organ will be concerned. Given the atypical presentation of the extrapulmonary illness, it poses a big diagnostic problem for the physicians; due to this fact, a excessive index of suspicion needs to be maintained, significantly the place tuberculosis is endemic. Right here we current a case of remoted chest wall tuberculosis in an immunocompetent affected person.

Weryfikacja modelu choroby opartego na czynnikach ludzkiego zakażenia Mycobacterium tuberculosis

phenomena in many various utility areas. Nonetheless, one of the crucial points, poorly investigated within the literature, regards an vital step of the mannequin credibility evaluation: resolution verification. This research overcomes this limitation by proposing a common verification framework for Agent-Primarily based Fashions that goals at evaluating the numerical errors related with the mannequin.

A step-by-step process, which consists of two essential verification research (deterministic and stochastic mannequin verification), is described intimately and utilized to a selected mission crucial situation: the quantification of the numerical approximation error for UISS-TB, an ABM of the human immune system developed to foretell the development of pulmonary tuberculosis.

Outcomes present indications on the risk to use the proposed mannequin verification workflow to systematically determine and quantify numerical approximation errors related to UISS-TB and, usually, with some other ABMs. This text is protected by copyright. All rights reserved.

Podtytuł immunologiczny w gruźlicy utajonej 

  • Latent tuberculosis an infection (LTBI) poses a serious roadblock within the international effort to eradicate tuberculosis (TB). A deep understanding of the host responses concerned in institution and upkeep of TB latency is required to propel the event of delicate strategies to detect and deal with LTBI. Provided that LTBI people are usually asymptomatic, it’s difficult to distinguish latently contaminated from uninfected people.
  • A significant contributor to this downside is that no clear sample of host response is linked with LTBI, as molecular correlates of latent an infection have been arduous to determine. On this research, we now have analyzed the worldwide perturbations in host response in LTBI people as in comparison with uninfected people and significantly the heterogeneity in such response, throughout LTBI cohorts.
  • For this, we constructed individualized genome-wide host response networks knowledgeable by blood transcriptomes for 136 LTBI circumstances and have used a delicate community mining algorithm to determine top-ranked host response subnetworks in every case.
  • Our evaluation signifies that regardless of the excessive heterogeneity within the gene expression profiles amongst LTBI samples, clear patterns of perturbation are present in the immune response pathways, resulting in grouping LTBI samples into Four totally different immune-subtypes. Our outcomes recommend that totally different subnetworks of molecular perturbations are related to latent tuberculosis.

Recombinant M. Tuberculosis HSP65

DAGA-194 0.1 mg Ask for price

M. Tuberculosis LAM

DAGA-168 1 mg
EUR 1434

M. Tuberculosis MPT53

DAGA-171 100 µg
EUR 868.8

M. Tuberculosis 38 kDa

DAG-T2447 1 mg Ask for price

M. Tuberculosis 16 kDa

DAG-T2449 1 mg Ask for price

M. Tuberculosis 15.3 kDa

DAGA-169 1 mg
EUR 1170

Recombinant Mycobacterium Tuberculosis HSP Protein

VAng-Yyj0063-10g 10 µg
EUR 2250
Description: Mycobacterium Tuberculosis, HSP, recombinant protein.

Mouse antibody for M. tuberculosis Hsp65

5177 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis Hsp65 for WB, ELISA.

Mouse antibody for M. tuberculosis Hsp65

5178 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis Hsp65 for WB, ELISA.

M. Tuberculosis TB22.2 Antigen

DAGA-186 100 µg
EUR 868.8

M. tuberculosis CFP10, Protein

abx061400-100ug 100 ug
EUR 961.2

M. tuberculosis ESAT6, Protein

abx061402-100ug 100 ug
EUR 910.8

M. Tuberculosis Mpt70 Antigen

DAGA-182 100 µg
EUR 868.8

M. Tuberculosis MPT83 Antigen

DAGA-183 100 µg
EUR 868.8

M. Tuberculosis Mpt64 Antigen

DAGA-184 100 µg
EUR 868.8

M. tuberculosis CFP10 Protein

abx061400-100g 100 µg Ask for price

M. tuberculosis CFP10 Protein

abx061400-10g 10 µg
EUR 1100

M. tuberculosis CFP10 Protein

abx061400-50g 50 µg Ask for price

M. Tuberculosis Rv2672 Antigen

DAGA-174 100 µg
EUR 868.8

M. Tuberculosis Rv2253 Antigen

DAGA-177 100 µg
EUR 868.8

M. Tuberculosis MT3413 Antigen

DAGA-178 100 µg
EUR 868.8

M. Tuberculosis Rv0477 Antigen

DAGA-179 100 µg
EUR 868.8

Mycobacterium tuberculosis HSP 70 Recombinant Protein

53-349 0.01 mg
EUR 789.9
Description: Mycobacterium tuberculosis HSP 70 Recombinant Protein

Mycobacterium tuberculosis 38 kDa Antigen (M. tuberculosis 38 kDa) Antibody

abx411025-02mg 0.2 mg
EUR 678

Mycobacterium tuberculosis 16 kDa Antigen (M. tuberculosis 16 kDa) Antibody

abx415759-01mg 0.1 mg
EUR 760.8

Mycobacterium tuberculosis 38 kDa Antigen (M. tuberculosis 38 kDa) Antibody

abx411025-100g 100 µg
EUR 487.5

Mycobacterium tuberculosis 16 kDa Antigen (M. tuberculosis 16 kDa) Antibody

abx415759-200l 200 µl
EUR 600

M. Tuberculosis Rv0192A Antigen

DAGA-173 100 µg
EUR 868.8

M. Tuberculosis Rv0398c Antigen

DAGA-176 100 µg
EUR 868.8

Recombinant M. tuberculosis 38kD

DAG-WT1091 1 mg
EUR 480
Description: Recombinant

M. Tuberculosis 38 kDa Protein

abx060636-100ug 100 ug
EUR 978

M. Tuberculosis 85-C Antigen

DAGA-175 100 µg
EUR 868.8

M. Tuberculosis 85-A Antigen

DAGA-181 100 µg
EUR 868.8

M. Tuberculosis 85-B Antigen

DAGA-185 100 µg
EUR 868.8

M. Tuberculosis 48 kDa protein

DAGA-191 1 mg Ask for price

M. Tuberculosis 38 kDa Protein

abx060636-100g 100 µg Ask for price

M. Tuberculosis 38 kDa Protein

abx060636-10g 10 µg
EUR 1437.5

M. Tuberculosis 38 kDa Protein

abx060636-50g 50 µg Ask for price

M. Tuberculosis 85A Antigen[his]

DAGA-189 10 µg
EUR 812.4

M. Tuberculosis 85A Antigen [His]

DAGA-192 50 µg
EUR 1228.8

M. Tuberculosis ESAT-6 Antigen

DAGA-187 100 µg
EUR 868.8

Native M. Tuberculosis LAM antigen

DAGC601 10 ug
EUR 978.6
Description: Native

Monoclonal Anti-M. tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2) IgG

HSP651-M 100 ul
EUR 578.4

Anti-Tb7.7 (M. tuberculosis) Purified

11-190-C100 0.1 mg
EUR 198

M. Tuberculosis Mpt63/MPB63 Antigen

DAGA-180 100 µg
EUR 868.8

Anti-Acr1 (M. tuberculosis) Purified

11-185-C100 0.1 mg
EUR 198

Anti-Tb10.4 (M. tuberculosis) Purified

11-186-C100 0.1 mg
EUR 198

Anti-Tb10.3 (M. tuberculosis) Purified

11-187-C100 0.1 mg
EUR 198

Anti-Acr2 (M. tuberculosis) Purified

11-188-C100 0.1 mg
EUR 198

Anti-GlcB (M. tuberculosis) Purified

11-192-C100 0.1 mg
EUR 198

Recombinant M. Tuberculosis CFP-10

DAGA-170 1 mg
EUR 790.8

M. Tuberculosis 63 kDa protein [His]

DAGA-190 1 mg Ask for price

Anti-Ag85b (M. tuberculosis) Purified

11-189-C100 0.1 mg
EUR 198

Zmp1 M. tuberculosis Recombinant Protein

90-361 50 ug
EUR 752.1
Description: M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.

Recombinant M. Tuberculosis Moex antigen

DAGA-213 1 mg Ask for price

M. Tuberculosis EsxB (LHP) (CFP10) Antigen

DAGA-188 100 µg
EUR 868.8

OPMA04822-100UG - M. tuberculosis Protein

OPMA04822-100UG 0.1MG
EUR 849

M. Tuberculosis ClpP Protease Assay Kit

TBP100K 100 assays
EUR 278.4
Description: This product includes 3100 ul of Assay Buffer and 310 ul of 10 x Substrate and 3500 ul of Stop solution. It is for 100 assays in 384-well plate format

Anti-CFP-10 (M. tuberculosis) Purified

11-490-C025 0.025 mg
EUR 99

Anti-CFP-10 (M. tuberculosis) Purified

11-490-C100 0.1 mg
EUR 198

Anti-ESAT-6 (M. tuberculosis) Purified

11-491-C025 0.025 mg
EUR 99

Anti-ESAT-6 (M. tuberculosis) Purified

11-491-C100 0.1 mg
EUR 198

Mouse antibody for M. tuberculosis 38kDa

5174 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis 38kDa for WB, ELISA.

Recombinant M. tuberculosis CFP10 (No tag)

DAG-WT1769 1 mg
EUR 1460
Description: Recombinant

Myobacterium Tuberculosis Heat Shock Protein 65 Protein

20-abx263477
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  • 100 ug
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  • 2 µg

Myobacterium Tuberculosis Heat Shock Protein 65 Protein

abx263477-10mg 10 mg
EUR 1362.5

Myobacterium Tuberculosis Heat Shock Protein 65 Protein

abx263477-1mg 1 mg
EUR 225

Myobacterium Tuberculosis Heat Shock Protein 65 Protein

abx263477-5mg 5 mg
EUR 325

Bacteria-Derived tuberculosis HSP 70 Recombinant Protein liquid

IBCTMYCBCTTBHSP70R10UG each
EUR 948
Description: Bacteria-Derived tuberculosis HSP 70 Recombinant Protein liquid

M. tuberculosis 38 kDa recombinant antigen

8811 100 ug
EUR 477.6
Description: This is M. tuberculosis 38 kDa recombinant antigen for ELISA,WB.

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody

20-abx109426
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody

abx109426-100l 100 µl
EUR 162.5

Mouse antibody for M. tuberculosis 16 kDa

5175 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis 16 kDa for WB, ELISA.

Mouse antibody for M. tuberculosis 16 kDa

5176 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis 16 kDa for WB, ELISA.

OAMA02759-1ML - A' M. tuberculosis Antibody

OAMA02759-1ML 1ml
EUR 549

M. Tuberculosis p60-Related Protein Rv0024

DAGA-172 100 µg
EUR 868.8

Recombinant M. tuberculosis 38kD antigen [His]

DAG-WT1188 200 µg, 1 mg Ask for price
Description: Recombinant

Recombinant Myobacterium Tuberculosis Heat Shock Protein 65

7-07048 2µg Ask for price

Recombinant Myobacterium Tuberculosis Heat Shock Protein 65

7-07049 10µg Ask for price

Recombinant Myobacterium Tuberculosis Heat Shock Protein 65

7-07050 100µg Ask for price

Recombinant M. tuberculosis Ag85B antigen [His]

DAG-WT1187 200 µg, 1 mg Ask for price
Description: Recombinant

Recombinant M. tuberculosis Mpt64 antigen [His]

DAG-WT1189 200 µg, 1 mg Ask for price
Description: Recombinant

Mycobacterium Tuberculosis Heat Shock Protein 65 (Recombinant)

22060736-1 2 µg
EUR 137.27

Heat Shock Protein 65 Mycobacterium Tuberculosis Recombinant

rAP-3428 Inquiry Ask for price

M. Tuberculosis ClpP Protease Assay Kit Plus

TBP100KE 100 assays
EUR 467.15
Description: This product includes 3000 ul of Assay Buffer, 310 ul of 10 x Substrate, 3500 ul of Stop solution and 31 ul of 100 x Mtb ClpP1P2 protease. It is for 100 assays in 384-well plate format

NAD Kinase M. tuberculosis Recombinant Protein

90-365 50 ug
EUR 651.3
Description: NAD kinase catalyzes the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. NAD kinase from Mycobacterium tuberculosis is not ATP-dependent but has a broader substrate specificity than human NAD kinase. It can economically produce NADP+ by using other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Was identified as a high-confidence drug target. Catalytic activity: ATP + NAD+ = ADP + NADP+

Rabbit polyclonal antibody for M. tuberculosis

4601 1 ml
EUR 340.57
Description: This is rabbit polyclonal antibody against M tuberculosis all antigens for WB, ELISA.

Rabbit polyclonal antibody for M. tuberculosis

4603 1 ml
EUR 360.16
Description: This is FITC conjugated rabbit polyclonal antibody against M tuberculosis all antigens for WB, ELISA.

Rabbit polyclonal antibody for M. tuberculosis

4607 1 ml
EUR 360.16
Description: This is Biotin conjugated rabbit polyclonal antibody against M tuberculosis all antigens for WB, ELISA.

OAMA02206-1MG - M tuberculosis CFP10 Antibody

OAMA02206-1MG 1mg
EUR 799

OAMA02208-1MG - M tuberculosis CFP10 Antibody

OAMA02208-1MG 1mg
EUR 799

Recombinant M. tuberculosis MTB39A Protein [His]

DAG-WT745 1 mg
EUR 1280
Description: Recombinant

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (FITC)

20-abx107752
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (HRP)

20-abx109170
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (Biotin)

20-abx106339
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  • 100 ug
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Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (HRP)

abx109170-100l 100 µl
EUR 162.5

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (FITC)

abx107752-100g 100 µg
EUR 362.5

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (FITC)

abx107752-20g 20 µg
EUR 162.5

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (FITC)

abx107752-50g 50 µg
EUR 250

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (Biotin)

abx106339-100g 100 µg
EUR 362.5

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (Biotin)

abx106339-20g 20 µg
EUR 162.5

Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] (M. tuberculosis inhA) Antibody (Biotin)

abx106339-50g 50 µg
EUR 250

Recombinant Mycobacterium Tuberculosis rpmD Protein (aa 1-65)

VAng-Yyj0608-50gEcoli 50 µg (E. coli)
EUR 1562.4
Description: Mycobacterium Tuberculosis 50S ribosomal protein L30 (rpmD), recombinant protein.

NAD Synthetase M. tuberculosis Recombinant Protein

90-366 50 ug
EUR 752.1
Description: NAD synthetase is an essential enzyme involved in both the de novo biosynthesis and salvage of NAD+, catalyzing the final step of both pathways. Since NAD has a vital role in cell metabolism, the enzyme represents a valid target for the development of new antimycobacterial agents. It can use both glutamine or ammonia as a nitrogen source. Catalytic activity: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate

Recombinant purified M. tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2) control for Western

HSP651-C 100 ul
EUR 343.2

Recombinant M. Tuberculosis EspC/Rv3615c(H37Rv) [His]

DAGA-3055 100ug
EUR 764.4

Ubiquitin 2 (Ub2, 65-76) peptide with anti-M. tuberculosis activity (STLHLVLRLRGG, MW:1321.6)

UBQ151-P 1 mg
EUR 182.4

Recombinant M. Tuberculosis Mpt64 Antigen (a.a.1-232)

DAG-WT1162 200 µg, 1 mg Ask for price
Description: Recombinant

Rabbit Anti-M. tuberculosis Tb7.7 Polyclonal antibody

DPAB-CS23047 100 μg
EUR 720
Description: Rabbit

IgG Antibody to M. Tuberculosis, TB-IgG ELISA Kit

DEIA083 96T
EUR 676.8
Description: This kit is anenzyme-linked immunosorbent assay for qualitative detection of IgG antibodies to Mycobacterium tuberculosis in human serum or plasma. It is intended for diagnosing and monitoring of patients related to infection by M. tuberculosis and other Mycobacteria.

human anti-M. tuberculosis lipoarabinomannan(LAM) IgG

E4A11A37-G 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-M. tuberculosis lipoarabinomannan(LAM) IgM

E4A11A37-M 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit Anti-M. tuberculosis Acr1 Polyclonal antibody

DPAB-CS23044 100 μg
EUR 720
Description: Rabbit

Rabbit Anti-M. tuberculosis Tb10.3 Polyclonal antibody

DPAB-CS23045 100 μg
EUR 720
Description: Rabbit

Rabbit Anti-M. tuberculosis Acr2 Polyclonal antibody

DPAB-CS23046 100 μg
EUR 720
Description: Rabbit

Rabbit Anti-M. tuberculosis GlcB Polyclonal antibody

DPAB-CS23048 100 μg
EUR 720
Description: Rabbit

Rabbit Anti-M. tuberculosis Tb10.4 Polyclonal antibody

DPAB-CS23053 100 μg
EUR 720
Description: Rabbit

Recombinant M. Tuberculosis CFP10: ESAT6 Chimera protein

DAGA-193 1 mg
EUR 2042.4

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-400l 400 µl Ask for price

Mycobacterium tuberculosis Hsp65 Antibody

abx022091-80l 80 µl
EUR 1287.5

MYCOBACTERIUM TUBERCULOSIS

GWB-FB7063 0.05 mg Ask for price

Mycobacterium tuberculosis

Oneq-VH201-OneqVH201100D Oneq-VH201-100D
EUR 515

Mycobacterium tuberculosis

Oneq-VH201-OneqVH201150D Oneq-VH201-150D
EUR 594

Mycobacterium tuberculosis

Oneq-VH201-OneqVH20150D Oneq-VH201-50D
EUR 413

Mycobacterium tuberculosis

PCR-VH201-PCRVH20148D PCR-VH201-48D
EUR 230

Mycobacterium tuberculosis

PCR-VH201-PCRVH20196D PCR-VH201-96D
EUR 312

Tuberculosis inhibitor 3

T38298-10mg 10mg Ask for price
Description: Tuberculosis inhibitor 3

Tuberculosis inhibitor 3

T38298-1g 1g Ask for price
Description: Tuberculosis inhibitor 3

Tuberculosis inhibitor 3

T38298-1mg 1mg Ask for price
Description: Tuberculosis inhibitor 3

Tuberculosis inhibitor 3

T38298-50mg 50mg Ask for price
Description: Tuberculosis inhibitor 3

Tuberculosis inhibitor 3

T38298-5mg 5mg Ask for price
Description: Tuberculosis inhibitor 3

Tuberculosis inhibitor 1

T13223-10mg 10mg Ask for price
Description: Tuberculosis inhibitor 1

Tuberculosis inhibitor 1

T13223-1g 1g Ask for price
Description: Tuberculosis inhibitor 1

Tuberculosis inhibitor 1

T13223-1mg 1mg Ask for price
Description: Tuberculosis inhibitor 1

Tuberculosis inhibitor 1

T13223-50mg 50mg Ask for price
Description: Tuberculosis inhibitor 1

Tuberculosis inhibitor 1

T13223-5mg 5mg Ask for price
Description: Tuberculosis inhibitor 1

Tuberculosis inhibitor 5

T62086-10mg 10mg Ask for price
Description: Tuberculosis inhibitor 5

Tuberculosis inhibitor 5

T62086-1g 1g Ask for price
Description: Tuberculosis inhibitor 5

Tuberculosis inhibitor 5

T62086-1mg 1mg Ask for price
Description: Tuberculosis inhibitor 5

Tuberculosis inhibitor 5

T62086-50mg 50mg Ask for price
Description: Tuberculosis inhibitor 5

Tuberculosis inhibitor 5

T62086-5mg 5mg Ask for price
Description: Tuberculosis inhibitor 5

Tuberculosis inhibitor 4

T62087-10mg 10mg Ask for price
Description: Tuberculosis inhibitor 4

Tuberculosis inhibitor 4

T62087-1g 1g Ask for price
Description: Tuberculosis inhibitor 4

Tuberculosis inhibitor 4

T62087-1mg 1mg Ask for price
Description: Tuberculosis inhibitor 4

Tuberculosis inhibitor 4

T62087-50mg 50mg Ask for price
Description: Tuberculosis inhibitor 4

Tuberculosis inhibitor 4

T62087-5mg 5mg Ask for price
Description: Tuberculosis inhibitor 4

Recombinant M. tuberculosis Ag85C Protein, His, E.coli-1mg

QP7382-ec-1mg 1mg
EUR 2763.6

Recombinant M. tuberculosis INHA Protein, His, Yeast-1mg

QP7385-ye-1mg 1mg
EUR 3296.4

Recombinant M. tuberculosis Ag85A Protein, His, E.coli-1mg

QP8929-ec-1mg 1mg
EUR 2763.6

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