Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny

Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny

Podwójne hamowanie mTORC1 / mTORC2 jako cel terapeutyczny ukierunkowany na gospodarza w patologicznie odmiennych mysich modelach gruźlicy 

Efforts to develop simpler and shorter-course therapies for tuberculosis have included a concentrate on host-directed remedy (HDT). The aim of HDT is to modulate the host response to an infection, thereby bettering immune defenses to scale back the length of antibacterial remedy and/or the quantity of lung harm.

As a mediator of innate and adaptive immune responses concerned in eliminating intracellular pathogens, autophagy is a possible goal for HDT in tuberculosis. As a result of Mycobacterium tuberculosis modulates mammalian goal of rapamycin (mTOR) signaling to impede autophagy, pharmacologic mTOR inhibition may present efficient HDT. mTOR exists inside two distinct multiprotein complexes, mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2).

Rapamycin and its analogs solely partially inhibit mTORC1. We hypothesized that novel mTOR kinase inhibitors blocking each complexes would have expanded therapeutic potential. We in contrast the consequences of two mTOR inhibitors: rapamycin and the orally obtainable mTOR kinase area inhibitor CC214-2, which blocks each mTORC1 and mTORC2, as adjunctive therapies in opposition to murine TB, when added to the first-line routine (RHZE) or the novel bedaquiline-pretomanid-linezolid (BPaL) routine.

Neither mTOR inhibitor affected lung CFU counts after 4-Eight weeks of remedy when mixed with BPaL or RHZE. Nonetheless, addition of CC214-2 to BPaL and RHZE was related to considerably fewer relapses in C3HeB/FeJ in comparison with addition of rapamycin and, in RHZE-treated mice, resulted in fewer relapses in comparison with RHZE alone. Due to this fact, CC214-2 and associated mTOR kinase inhibitors could also be simpler candidates for HDT than rapamycin analogs and will have the potential to shorten the length of TB remedy.

 

patogeny2019
patogeny2019

Mycobacterium tuberculosis ESAT6

MBS6506783-01mg 0.1mg
EUR 760

Mycobacterium tuberculosis ESAT6

MBS6506783-5x01mg 5x0.1mg
EUR 3265

mycobacterium tuberculosis ESAT6 Recombinant Protein

PROTP9WNK6 10ug
EUR 265
Description: Mycobacterium tuberculosis ESAT6 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 1-95aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-1mg 1 mg
EUR 2030.4

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-100g 100 µg Ask for price

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-10g 10 µg
EUR 2150

Mycobacterium tuberculosis CFP10: ESAT6 Chimera Protein

abx061560-50g 50 µg Ask for price

Mycobacterium tuberculosis CFP10: ESAT6 Chimera, Recombinant

MBS313439-1mg 1mg
EUR 1635

Mycobacterium tuberculosis CFP10: ESAT6 Chimera, Recombinant

MBS313439-5x1mg 5x1mg
EUR 7120

ESAT6, 1-95aa, Mycobacterium tuberculosis, His tag, Baculovirus

MBS204541-001mg 0.01mg
EUR 230

ESAT6, 1-95aa, Mycobacterium tuberculosis, His tag, Baculovirus

MBS204541-005mg 0.05mg
EUR 405

ESAT6, 1-95aa, Mycobacterium tuberculosis, His tag, Baculovirus

MBS204541-025mg 0.25mg
EUR 985

ESAT6, 1-95aa, Mycobacterium tuberculosis, His tag, Baculovirus

MBS204541-5x025mg 5x0.25mg
EUR 4180

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (PE)

MBS6129470-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (PE)

MBS6129470-5x01mL 5x0.1mL
EUR 4670

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (AP)

MBS6126374-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (AP)

MBS6126374-5x01mL 5x0.1mL
EUR 4670

Mycobacterium tuberculosis antigen EsaT-6 (Rv3875) Antibody

abx140048-01mg 0.1 mg
EUR 510

Mycobacterium tuberculosis antigen EsaT-6 (Rv3875) Antibody

abx140048-100g 100 µg
EUR 350

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (HRP)

MBS6128850-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (HRP)

MBS6128850-5x01mL 5x0.1mL
EUR 4670

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (APC)

MBS6126994-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (APC)

MBS6126994-5x01mL 5x0.1mL
EUR 4670

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (FITC)

MBS6128229-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (FITC)

MBS6128229-5x01mL 5x0.1mL
EUR 4670

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (Biotin)

MBS6127615-01mL 0.1(mL
EUR 1070

Mycobacterium tuberculosis ESAT6 (6kD Early Secretory Antigen of T Cells) (Biotin)

MBS6127615-5x01mL 5x0.1mL
EUR 4670

Recombinant chimeric antigen CFP10:ESAT6 for Mycobacterium tuberculosis (Koch's bacillus)

MBS505078-1mg 1mg
EUR 1210

Recombinant chimeric antigen CFP10:ESAT6 for Mycobacterium tuberculosis (Koch's bacillus)

MBS505078-5x1mg 5x1mg
EUR 5145

Recombinant Mycobacterium tuberculosis ESAT-6

DAGH171 1 mg
EUR 630
Description: Recombinant

Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

1-CSB-YP363658MVZ
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB(esxB) expressed in Yeast

Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

1-CSB-EP363658MVZ
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB(esxB) expressed in E.coli

Mycobacterium tuberculosis ESAT-6-like protein EsxH (esxH)

1-CSB-EP363659MVZ
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  • 100ug
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  • 200ug
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Description: Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH(esxH),partial expressed in E.coli

Mycobacterium tuberculosis (ESAT) mouse monoclonal antibody, clone RSB14

3ES6-RSB14 1 mg Ask for price

Mycobacterium tuberculosis (ESAT) mouse monoclonal antibody, clone RSB34

3ES6-RSB34 1 mg Ask for price

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-1ml 1 ml
EUR 727.2

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-200l 200 µl
EUR 537.5

Recombinant purified (E. coli) Mycobacterium tuberculosis antigen (6kDa/ESAT-6)

MTB06-R 100 ug
EUR 927.6

Recombinant Mycobacterium Tuberculosis ESAT-6 Protein (aa 1-99) [His]

VAng-Lsx06137-100g 100 µg
EUR 717.6
Description: Mycobacterium Tuberculosis (H37Rv) ESAT-6, recombinant protein from E. coli.

Recombinant Mycobacterium Tuberculosis ESAT-6 Protein (aa 1-99) [His]

VAng-Lsx06137-1mg 1 mg
EUR 3686.4
Description: Mycobacterium Tuberculosis (H37Rv) ESAT-6, recombinant protein from E. coli.

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS1103807-002mgEColi 0.02mg(E-Coli)
EUR 375

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS1103807-01mgEColi 0.1mg(E-Coli)
EUR 635

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS1103807-1mgEColi 1mg(E-Coli)
EUR 1925

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS1103807-5x1mgEColi 5x1mg(E-Coli)
EUR 8405

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS9421049-002mg 0.02mg
EUR 460

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS9421049-01mg 0.1mg
EUR 795

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS9421049-1mg 1mg
EUR 2525

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxH

MBS9421049-5x1mg 5x1mg
EUR 11205

Mycobacterium tuberculosis Antibody

abx022066-1mg 1 mg
EUR 1220.4

Mycobacterium tuberculosis Antibody

abx022067-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis Antibody

abx022073-1mg 1 mg
EUR 1296

Mycobacterium tuberculosis Antibody

abx022087-1mg 1 mg
EUR 994.8

Mycobacterium tuberculosis Antibody

abx022088-1mg 1 mg
EUR 994.8

Mycobacterium tuberculosis Antibody

abx022089-1mg 1 mg
EUR 944.4

Mycobacterium tuberculosis Antibody

abx022090-1mg 1 mg
EUR 944.4

Mycobacterium tuberculosis Antibody

abx023092-1ml 1 ml
EUR 718.8

Mycobacterium tuberculosis antibody

20-MR50 1 mg
EUR 110
Description: Rabbit polyclonal Mycobacterium tuberculosis antibody

Mycobacterium tuberculosis Antibody

GWB-37A518 0.5 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-52959A 1 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-613CF2 1 ml Ask for price

Mycobacterium tuberculosis, Antibody

GWB-1A49B9 0.1 mg Purified Ask for price

Mycobacterium tuberculosis Antibody

GWB-AE5BA3 1 ml Ask for price

Mycobacterium Tuberculosis Antibody

GWB-EF714E 1 ml Ask for price

Mycobacterium tuberculosis Antibody

GWB-CAE926 1 ml Ask for price

Mycobacterium tuberculosis Antibody

abx022066-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022066-80l 80 µl
EUR 1200

Mycobacterium tuberculosis Antibody

abx022067-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022067-80l 80 µl
EUR 1287.5

Mycobacterium tuberculosis Antibody

abx022073-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx022073-80l 80 µl
EUR 1287.5

Mycobacterium tuberculosis Antibody

abx023092-400l 400 µl Ask for price

Mycobacterium tuberculosis Antibody

abx023092-80l 80 µl
EUR 1012.5

Mycobacterium tuberculosis Antibody

MBS568506-05mL 0.5mL
EUR 305

Mycobacterium tuberculosis Antibody

MBS568506-5x05mL 5x0.5mL
EUR 1180

Mycobacterium tuberculosis antibody

MBS534825-1mg 1mg
EUR 240

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB (esxB)

CSB-YP363658MVZ 6400 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxB(esxB)

AP72990 each Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB(esxB)

AP76578 1mg
EUR 2826

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

CSB-EP363658MVZ 3423 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein EsxB (esxB)

CSB-EP363658MVZb2 3424 mg Ask for price

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxN (esxN)

MBS1176177-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1015

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxN (esxN)

MBS1176177-002mgEColi 0.02mg(E-Coli)
EUR 590

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxN (esxN)

MBS1176177-002mgYeast 0.02mg(Yeast)
EUR 770

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxN (esxN)

MBS1176177-01mgEColi 0.1mg(E-Coli)
EUR 700

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxN (esxN)

MBS1176177-01mgYeast 0.1mg(Yeast)
EUR 900

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxL (esxL)

MBS1030972-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1015

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxL (esxL)

MBS1030972-002mgEColi 0.02mg(E-Coli)
EUR 590

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxL (esxL)

MBS1030972-002mgYeast 0.02mg(Yeast)
EUR 770

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxL (esxL)

MBS1030972-01mgEColi 0.1mg(E-Coli)
EUR 700

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxL (esxL)

MBS1030972-01mgYeast 0.1mg(Yeast)
EUR 900

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxK (esxK)

MBS1026654-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1020

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxK (esxK)

MBS1026654-002mgEColi 0.02mg(E-Coli)
EUR 595

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxK (esxK)

MBS1026654-002mgYeast 0.02mg(Yeast)
EUR 775

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxK (esxK)

MBS1026654-01mgEColi 0.1mg(E-Coli)
EUR 705

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxK (esxK)

MBS1026654-01mgYeast 0.1mg(Yeast)
EUR 905

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxR (esxR)

MBS1152984-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1020

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxR (esxR)

MBS1152984-002mgEColi 0.02mg(E-Coli)
EUR 590

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxR (esxR)

MBS1152984-002mgYeast 0.02mg(Yeast)
EUR 775

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxR (esxR)

MBS1152984-01mgEColi 0.1mg(E-Coli)
EUR 700

Recombinant Mycobacterium tuberculosis ESAT-6-like protein esxR (esxR)

MBS1152984-01mgYeast 0.1mg(Yeast)
EUR 905

Reprezentowanie przenoszenia gruźlicy ze złożonym zakażeniem: podejście do modelowania symulacyjnego opartego na agentach

Goal: A latest research reported a tuberculosis (TB) outbreak through which, amongst newly contaminated people, publicity to extra energetic infections was related to a better likelihood of creating energetic illness. Known as complicated contagion, a number of reexposures to TB inside a brief interval after preliminary an infection is hypothesized to confer a better chance of creating energetic an infection in 1 y. The aim of this text is to develop and validate an agent-based simulation mannequin (ABM) to review the impact of complicated contagion on population-level TB transmission dynamics.

Strategies: We constructed an ABM of a TB epidemic utilizing knowledge from a sequence of outbreaks recorded within the 20th century in Saskatchewan, Canada. We match three dynamical schemes: base, with no complicated contagion; additive, through which every reexposure confers an unbiased threat of activated an infection; and threshold, through which a small variety of reexposures confers a low threat and a excessive variety of reexposures confers a excessive threat of activation.

Outcomes: We discover that the bottom mannequin suits the mortality and incidence output targets greatest, adopted by the edge after which the additive fashions. The edge mannequin suits the incidence higher than the bottom mannequin does however overestimates mortality. All three fashions produce qualitatively lifelike epidemic curves.

Conclusion: We discover that complicated contagion qualitatively modifications the trajectory of a TB epidemic, though knowledge from a high-incidence setting are reproduced higher with the bottom mannequin. Outcomes from this mannequin show the feasibility of utilizing ABM to seize nuances in TB transmission.

Opis przypadku gruźlicy w palcu 

Tuberculosis is a persistent, infectious illness that predominantly impacts the respiratory system. Of the least frequent extrapulmonary types of the illness is cutaneous tuberculosis. We current an uncommon case, which is of cutaneous tuberculosis within the finger, manifesting as an ulcerating, erythematous lesion. This had later unfold to the adjoining tender tissue and bones, inflicting osteomyelitis of the phalanges. It will be significant that physicians keep a excessive index of suspicion when confronted with atypical pores and skin lesions to keep away from the sequelae of the native and disseminated unfold of a tuberculosis an infection.

Gruźlica pozapłucna udająca złośliwość ściany klatki piersiowej: po prostu nigdy nie przestaje zaskakiwać! 

With the emergence of the acquired immunodeficiency syndrome, we witnessed a better incidence of disseminated and extrapulmonary tuberculosis. The an infection websites generally embody lymph nodes, pleura, and osteoarticular areas, though any organ will be concerned. Given the atypical presentation of the extrapulmonary illness, it poses a big diagnostic problem for the physicians; due to this fact, a excessive index of suspicion needs to be maintained, significantly the place tuberculosis is endemic. Right here we current a case of remoted chest wall tuberculosis in an immunocompetent affected person.

Weryfikacja modelu choroby opartego na czynnikach ludzkiego zakażenia Mycobacterium tuberculosis

phenomena in many various utility areas. Nonetheless, one of the crucial points, poorly investigated within the literature, regards an vital step of the mannequin credibility evaluation: resolution verification. This research overcomes this limitation by proposing a common verification framework for Agent-Primarily based Fashions that goals at evaluating the numerical errors related with the mannequin.

A step-by-step process, which consists of two essential verification research (deterministic and stochastic mannequin verification), is described intimately and utilized to a selected mission crucial situation: the quantification of the numerical approximation error for UISS-TB, an ABM of the human immune system developed to foretell the development of pulmonary tuberculosis.

Outcomes present indications on the risk to use the proposed mannequin verification workflow to systematically determine and quantify numerical approximation errors related to UISS-TB and, usually, with some other ABMs. This text is protected by copyright. All rights reserved.

Podtytuł immunologiczny w gruźlicy utajonej 

  • Latent tuberculosis an infection (LTBI) poses a serious roadblock within the international effort to eradicate tuberculosis (TB). A deep understanding of the host responses concerned in institution and upkeep of TB latency is required to propel the event of delicate strategies to detect and deal with LTBI. Provided that LTBI people are usually asymptomatic, it’s difficult to distinguish latently contaminated from uninfected people.
  • A significant contributor to this downside is that no clear sample of host response is linked with LTBI, as molecular correlates of latent an infection have been arduous to determine. On this research, we now have analyzed the worldwide perturbations in host response in LTBI people as in comparison with uninfected people and significantly the heterogeneity in such response, throughout LTBI cohorts.
  • For this, we constructed individualized genome-wide host response networks knowledgeable by blood transcriptomes for 136 LTBI circumstances and have used a delicate community mining algorithm to determine top-ranked host response subnetworks in every case.
  • Our evaluation signifies that regardless of the excessive heterogeneity within the gene expression profiles amongst LTBI samples, clear patterns of perturbation are present in the immune response pathways, resulting in grouping LTBI samples into Four totally different immune-subtypes. Our outcomes recommend that totally different subnetworks of molecular perturbations are related to latent tuberculosis.

Mycobacterium tuberculosis 16kD (M. tuberculosis)

MBS6009340-5x1mg 5x1mg
EUR 3830

Mycobacterium tuberculosis 16kD (M. tuberculosis)

MBS6011625-1mg 1(mg
EUR 1295

Mycobacterium tuberculosis 16kD (M. tuberculosis)

MBS6011625-5x1mg 5x1mg
EUR 5675

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-1ml 1 ml
EUR 727.2

Mycobacterium tuberculosis (M. tuberculosis) Antibody

abx415707-200l 200 µl
EUR 537.5

Mycobacterium tuberculosis, HSP, Recombinant

MBS636978-01mg 0.1mg
EUR 735

Mycobacterium tuberculosis, HSP, Recombinant

MBS636978-5x01mg 5x0.1mg
EUR 3165

M. Tuberculosis HSP70 Protein

abx060544-100ug 100 ug
EUR 1378.8

Mycobacterium tuberculosis 16kD (M. tuberculosis) (PE)

MBS6129466-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (PE)

MBS6129466-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (PE)

MBS6129467-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (PE)

MBS6129467-5x01mL 5x0.1mL
EUR 4775

Mycobacterium tuberculosis 16kD (M. tuberculosis) (AP)

MBS6126370-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (AP)

MBS6126370-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (AP)

MBS6126371-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (AP)

MBS6126371-5x01mL 5x0.1mL
EUR 4775

Mycobacterium tuberculosis 16kD (M. tuberculosis) (HRP)

MBS6128846-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (HRP)

MBS6128846-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (HRP)

MBS6128847-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (HRP)

MBS6128847-5x01mL 5x0.1mL
EUR 4775

Mycobacterium tuberculosis 16kD (M. tuberculosis) (APC)

MBS6126990-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (APC)

MBS6126990-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (APC)

MBS6126991-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (APC)

MBS6126991-5x01mL 5x0.1mL
EUR 4775

Mycobacterium tuberculosis 16kD (M. tuberculosis) (FITC)

MBS6128225-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (FITC)

MBS6128225-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (FITC)

MBS6128226-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (FITC)

MBS6128226-5x01mL 5x0.1mL
EUR 4775

Recombinant M. Tuberculosis HSP65

DAGA-194 0.1 mg Ask for price

Mycobacterium tuberculosis 16kD (M. tuberculosis) (Biotin)

MBS6127611-01mL 0.1(mL
EUR 1240

Mycobacterium tuberculosis 16kD (M. tuberculosis) (Biotin)

MBS6127611-5x01mL 5x0.1mL
EUR 5430

Mycobacterium tuberculosis 16kD (M. tuberculosis) (Biotin)

MBS6127612-01mL 0.1(mL
EUR 1095

Mycobacterium tuberculosis 16kD (M. tuberculosis) (Biotin)

MBS6127612-5x01mL 5x0.1mL
EUR 4775

M. Tuberculosis LAM

DAGA-168 1 mg
EUR 1434

M. Tuberculosis MPT53

DAGA-171 100 µg
EUR 868.8

Recombinant Mycobacterium Tuberculosis HSP Protein

VAng-Yyj0063-10g 10 µg
EUR 2250
Description: Mycobacterium Tuberculosis, HSP, recombinant protein.

M. Tuberculosis 38 kDa

DAG-T2447 1 mg Ask for price

M. Tuberculosis 16 kDa

DAG-T2449 1 mg Ask for price

M. Tuberculosis 15.3 kDa

DAGA-169 1 mg
EUR 1170

MAb to M. tuberculosis

MBS310270-1mg 1mg
EUR 955

MAb to M. tuberculosis

MBS310270-5x1mg 5x1mg
EUR 4115

MAb to M. tuberculosis

MBS310271-1mg 1mg
EUR 1035

MAb to M. tuberculosis

MBS310271-5x1mg 5x1mg
EUR 4485

MAb to M. tuberculosis

MBS310272-1mg 1mg
EUR 1035

MAb to M. tuberculosis

MBS310272-5x1mg 5x1mg
EUR 4485

MAb to M. tuberculosis

MBS310273-1mg 1mg
EUR 1035

MAb to M. tuberculosis

MBS310273-5x1mg 5x1mg
EUR 4485

Mouse antibody for M. tuberculosis Hsp65

5177 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis Hsp65 for WB, ELISA.

Mouse antibody for M. tuberculosis Hsp65

5178 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against M tuberculosis Hsp65 for WB, ELISA.

Mycobacterium tuberculosis HSP 70 Recombinant Protein

53-349 0.01 mg
EUR 789.9
Description: Mycobacterium tuberculosis HSP 70 Recombinant Protein

Rabbit A' M. tuberculosis

MBS315160-1mL 1mL
EUR 855

Rabbit A' M. tuberculosis

MBS315160-5x1mL 5x1mL
EUR 3685

Rabbit A' M. tuberculosis

MBS315161-1mL 1mL
EUR 915

Rabbit A' M. tuberculosis

MBS315161-5x1mL 5x1mL
EUR 3945

Rabbit A' M. tuberculosis

MBS315162-1mL 1mL
EUR 915

Rabbit A' M. tuberculosis

MBS315162-5x1mL 5x1mL
EUR 3945

Rabbit A' M. tuberculosis

MBS315163-1mL 1mL
EUR 800

Rabbit A' M. tuberculosis

MBS315163-5x1mL 5x1mL
EUR 3420

M. Tuberculosis TB22.2 Antigen

DAGA-186 100 µg
EUR 868.8

M. tuberculosis Moex protein

MBS596054-1mg 1mg
EUR 425

M. tuberculosis Moex protein

MBS596054-2mg 2mg
EUR 700

M. tuberculosis Moex protein

MBS596054-5mg 5mg
EUR 1505

M. tuberculosis CFP10, Recomb.

MBS319838-01mg 0.1mg
EUR 755

M. tuberculosis CFP10, Recomb.

MBS319838-5x01mg 5x0.1mg
EUR 3165

M. tuberculosis CFP10, Protein

abx061400-100ug 100 ug
EUR 961.2

M. tuberculosis ESAT6, Protein

abx061402-100ug 100 ug
EUR 910.8

M. Tuberculosis Mpt70 Antigen

DAGA-182 100 µg
EUR 868.8

M. Tuberculosis MPT83 Antigen

DAGA-183 100 µg
EUR 868.8

M. Tuberculosis Mpt64 Antigen

DAGA-184 100 µg
EUR 868.8

M. tuberculosis CFP10 Protein

abx061400-100g 100 µg Ask for price

M. tuberculosis CFP10 Protein

abx061400-10g 10 µg
EUR 1100

M. tuberculosis CFP10 Protein

abx061400-50g 50 µg Ask for price

Monoclonal Anti-M. tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2) IgG

HSP651-M 100 ul
EUR 578.4

M. Tuberculosis Rv2672 Antigen

DAGA-174 100 µg
EUR 868.8

M. Tuberculosis Rv2253 Antigen

DAGA-177 100 µg
EUR 868.8

M. Tuberculosis MT3413 Antigen

DAGA-178 100 µg
EUR 868.8

M. Tuberculosis Rv0477 Antigen

DAGA-179 100 µg
EUR 868.8

M. Tuberculosis Rv0192A Antigen

DAGA-173 100 µg
EUR 868.8

M. Tuberculosis Rv0398c Antigen

DAGA-176 100 µg
EUR 868.8

Mycobacterium tuberculosis 38 kDa Antigen (M. tuberculosis 38 kDa) Antibody

abx411025-02mg 0.2 mg
EUR 678

Mycobacterium tuberculosis 16 kDa Antigen (M. tuberculosis 16 kDa) Antibody

abx415759-01mg 0.1 mg
EUR 760.8

Mycobacterium tuberculosis 16 kDa Antigen (M. tuberculosis 16 kDa) Antibody

abx415759-200l 200 µl
EUR 600

Mycobacterium tuberculosis 38 kDa Antigen (M. tuberculosis 38 kDa) Antibody

abx411025-100g 100 µg
EUR 487.5

Mab to M. tuberculosis MPT64

MBS313702-1mg 1mg
EUR 515

Mab to M. tuberculosis MPT64

MBS313702-5x1mg 5x1mg
EUR 2135

Mab to M. tuberculosis MPT64

MBS313703-1mg 1mg
EUR 515

Mab to M. tuberculosis MPT64

MBS313703-5x1mg 5x1mg
EUR 2135

Mab to M. tuberculosis MPT64

MBS313704-1mg 1mg
EUR 515

Mab to M. tuberculosis MPT64

MBS313704-5x1mg 5x1mg
EUR 2135

Mab to M. tuberculosis MPT64

MBS313705-1mg 1mg
EUR 515

Mab to M. tuberculosis MPT64

MBS313705-5x1mg 5x1mg
EUR 2135

M. tuberculosis MPT64 Rec. Ag

MBS313721-1mg 1mg
EUR 515

M. tuberculosis MPT64 Rec. Ag

MBS313721-5x1mg 5x1mg
EUR 2155

M. tuberculosis MPT64 Rec. Ag

MBS313722-1mg 1mg
EUR 515

M. tuberculosis MPT64 Rec. Ag

MBS313722-5x1mg 5x1mg
EUR 2155

MAb to M. tuberculosis, 16kDa

MBS310461-1mg 1mg
EUR 605

MAb to M. tuberculosis, 16kDa

MBS310461-5x1mg 5x1mg
EUR 2640

MAb to M. tuberculosis, 38kDa

MBS310523-1mg 1mg
EUR 605

MAb to M. tuberculosis, 38kDa

MBS310523-5x1mg 5x1mg
EUR 2640

MAb to M. tuberculosis CFP10

MBS312553-1mg 1mg
EUR 805

MAb to M. tuberculosis CFP10

MBS312553-5x1mg 5x1mg
EUR 3455

MAb to M. tuberculosis CFP10

MBS312555-1mg 1mg
EUR 805

MAb to M. tuberculosis CFP10

MBS312555-5x1mg 5x1mg
EUR 3455

Recombinant M. tuberculosis 38kD

DAG-WT1091 1 mg
EUR 480
Description: Recombinant

M. tuberculosis, 38kDa, Recombinant

MBS319392-01mg 0.1mg
EUR 1150

M. tuberculosis, 38kDa, Recombinant

MBS319392-5x01mg 5x0.1mg
EUR 4995

Heat Shock Protein 65, Recombinant, Mycobacterium tuberculosis (HSP65)

MBS636130-0002mg 0.002mg
EUR 390

Heat Shock Protein 65, Recombinant, Mycobacterium tuberculosis (HSP65)

MBS636130-001mg 0.01mg
EUR 540

Heat Shock Protein 65, Recombinant, Mycobacterium tuberculosis (HSP65)

MBS636130-5x001mg 5x0.01mg
EUR 2275

M. Tuberculosis 38 kDa Protein

abx060636-100ug 100 ug
EUR 978

M. Tuberculosis 85-C Antigen

DAGA-175 100 µg
EUR 868.8

M. Tuberculosis 85-A Antigen

DAGA-181 100 µg
EUR 868.8

M. Tuberculosis 85-B Antigen

DAGA-185 100 µg
EUR 868.8

M. Tuberculosis 48 kDa protein

DAGA-191 1 mg Ask for price

M. Tuberculosis 38 kDa Protein

abx060636-100g 100 µg Ask for price

M. Tuberculosis 38 kDa Protein

abx060636-10g 10 µg
EUR 1437.5

M. Tuberculosis 38 kDa Protein

abx060636-50g 50 µg Ask for price

M. Tuberculosis 85A Antigen[his]

DAGA-189 10 µg
EUR 812.4

M. Tuberculosis 85A Antigen [His]

DAGA-192 50 µg
EUR 1228.8

M. Tuberculosis ESAT-6 Antigen

DAGA-187 100 µg
EUR 868.8

Native M. Tuberculosis LAM antigen

DAGC601 10 ug
EUR 978.6
Description: Native

Anti-Tb7.7 (M. tuberculosis) Purified

11-190-C100 0.1 mg
EUR 198

M. Tuberculosis Mpt63/MPB63 Antigen

DAGA-180 100 µg
EUR 868.8

Anti-Tb7.7 (M. tuberculosis) Purified

MBS1801449-01mg 0.1mg
EUR 305

Anti-Tb7.7 (M. tuberculosis) Purified

MBS1801449-5x01mg 5x0.1mg
EUR 1120

Anti-Acr1 (M. tuberculosis) Purified

11-185-C100 0.1 mg
EUR 198

Anti-Tb10.4 (M. tuberculosis) Purified

11-186-C100 0.1 mg
EUR 198

Anti-Tb10.3 (M. tuberculosis) Purified

11-187-C100 0.1 mg
EUR 198

Anti-Acr2 (M. tuberculosis) Purified

11-188-C100 0.1 mg
EUR 198

Anti-GlcB (M. tuberculosis) Purified

11-192-C100 0.1 mg
EUR 198

Recombinant M. Tuberculosis CFP-10

DAGA-170 1 mg
EUR 790.8

Anti-Acr1 (M. tuberculosis) Purified

MBS1801444-01mg 0.1mg
EUR 305

Anti-Acr1 (M. tuberculosis) Purified

MBS1801444-5x01mg 5x0.1mg
EUR 1120

Anti-Tb10.4 (M. tuberculosis) Purified

MBS1801445-01mg 0.1mg
EUR 305

Anti-Tb10.4 (M. tuberculosis) Purified

MBS1801445-5x01mg 5x0.1mg
EUR 1120

Anti-Tb10.3 (M. tuberculosis) Purified

MBS1801446-01mg 0.1mg
EUR 305

Anti-Tb10.3 (M. tuberculosis) Purified

MBS1801446-5x01mg 5x0.1mg
EUR 1120

Anti-Acr2 (M. tuberculosis) Purified

MBS1801447-01mg 0.1mg
EUR 305

Anti-Acr2 (M. tuberculosis) Purified

MBS1801447-5x01mg 5x0.1mg
EUR 1120

Anti-GlcB (M. tuberculosis) Purified

MBS1801450-01mg 0.1mg
EUR 305

Anti-GlcB (M. tuberculosis) Purified

MBS1801450-5x01mg 5x0.1mg
EUR 1120

Anti-Ag85b (M. tuberculosis) Purified

11-189-C100 0.1 mg
EUR 198

Anti-Ag85b (M. tuberculosis) Purified

MBS1801448-01mg 0.1mg
EUR 305

Anti-Ag85b (M. tuberculosis) Purified

MBS1801448-5x01mg 5x0.1mg
EUR 1120

M. Tuberculosis 63 kDa protein [His]

DAGA-190 1 mg Ask for price

Bacteria-Derived tuberculosis HSP 70 Recombinant Protein liquid

IBCTMYCBCTTBHSP70R10UG each
EUR 948
Description: Bacteria-Derived tuberculosis HSP 70 Recombinant Protein liquid

Bacteria-Derived tuberculosis HSP 70 Recombinant Protein liquid

MBS8430610-INQUIRE INQUIRE Ask for price

Zmp1 M. tuberculosis Recombinant Protein

90-361 50 ug
EUR 752.1
Description: M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.

Recombinant M. Tuberculosis Moex antigen

DAGA-213 1 mg Ask for price

Myobacterium Tuberculosis Heat Shock Protein 65 Protein

20-abx263477
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 2 µg

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